GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7714584 | 1 | rs4958842 | chr5:150224877 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.2 | 1.23E-9 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs4958842 | chr5:150224877 | ZNF300 | chr5:150273964-150284391:- | 0.17 | 3.42 | 0.000689 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs4958843 | chr5:150224924 | LOC134466 | chr5:150310000-150326146:- | 0.39 | 5.45 | 8.07E-8 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs4958848 | chr5:150271122 | LOC134466 | chr5:150310000-150326146:- | 0.38 | 5.28 | 2.01E-7 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs4958852 | chr5:150330631 | LOC134466 | chr5:150310000-150326146:- | 0.44 | 5.48 | 6.9E-8 | Crohn's disease |
| THCA | cis | rs7386474 | 1 | rs4961372 | chr8:142358865 | TRAPPC9 | chr8:140742586-141468678:- | 0.13 | 3.36 | 0.000844 | Bipolar disorder and schizophrenia |
| THCA | cis | rs2251844 | 1 | rs496584 | chr15:43831923 | ADAL | chr15:43622872-43646094:+ | -0.5 | -11.36 | 1.28E-26 | Tumor biomarkers |
| THCA | cis | rs2251844 | 1 | rs496584 | chr15:43831923 | CATSPER2 | chr15:43922774-43959900:- | -0.27 | -4.8 | 2.11E-6 | Tumor biomarkers |
| THCA | cis | rs2251844 | 1 | rs496584 | chr15:43831923 | STRC | chr15:43891762-43924561:- | 0.34 | 6.22 | 1.1E-9 | Tumor biomarkers |
| THCA | cis | rs2251844 | 1 | rs496584 | chr15:43831923 | TUBGCP4 | chr15:43663313-43698238:+ | 0.12 | 3.37 | 0.000819 | Tumor biomarkers |
| THCA | cis | rs4357530 | 1 | rs4970941 | chr1:151068546 | BNIPL | chr1:151009029-151020076:+ | -0.18 | -3.65 | 0.000292 | Body mass index |
| THCA | cis | rs4925540 | 1 | rs4971316 | chr1:247210903 | OR2T8 | chr1:248084320-248085256:+ | -0.18 | -3.43 | 0.000665 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs4925540 | 1 | rs4971316 | chr1:247210903 | OR2W3 | chr1:248031265-248060142:+ | -0.18 | -3.62 | 0.000328 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs4925540 | 1 | rs4971316 | chr1:247210903 | TRIM58 | chr1:248020501-248043436:+ | -0.15 | -3.38 | 0.000771 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs4925540 | 1 | rs4971319 | chr1:247211565 | OR2T8 | chr1:248084320-248085256:+ | -0.18 | -3.43 | 0.000665 | Response to taxane treatment (docetaxel) |